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Article

Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2010

Kaufmann Beat A, Carr Chad L, Belcik J Todd, Xie Aris, Yue Qi, Chadderdon Scott, Caplan Evan S, Khangura Jaspreet, Bullens Sherry, Bunting Stuart, Lindner Jonathan R

Abstract excerpt

UNLABELLED: Background- We hypothesized that molecular imaging of endothelial cell adhesion molecule expression could noninvasively evaluate prelesion atherogenic phenotype. METHODS AND RESULTS: Mice deficient for the LDL-receptor and the Apobec-1 editing peptide (DKO mice) were studied as an age-dependent model of atherosclerosis. At 10, 20, and 40 weeks of age, ultrasound molecular imaging of the proximal...

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Identifiers

PMID: 19834105
DOI: 10.1161/ATVBAHA.109.196386
PMCID: PMC2814530

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