Article
Isolation and molecular characterization of the B cells producing the paraprotein in a case of benign monoclonal gammapathy in C57BL mice.
European journal of immunology - 1 Aug 1991
Bos N A, Meeuwsen C G, De Glopper-Van der Veer E, van den Akker T W, Radl J, Zwaagstra K A, Benner R
Abstract excerpt
Benign monoclonal gammapathy (BMG) is defined as a benign monoclonal B cell proliferative disorder characterized by the presence of a persisting component of homogenous immunoglobulins (H-Ig) in the serum. A possible role of antigenic stimulation in the development of BMG has been suggested. From...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Hybridomas
- Hypergammaglobulinemia
- Immune Sera
- Immunoglobulin G
- Immunoglobulin M
- Isoelectric Focusing
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- RNA, Messenger