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Article

A mouse with a monoclonal primary immunoglobulin repertoire not further diversified by V-gene replacement.

Developmental immunology - 1 Jan 1999

Cascalho M, Martin D A, Wong J, Lam Q, Wabl M, Wu G E

Abstract excerpt

We have generated a monoclonal B-cell mouse by introducing homozygous, nonfunctional RAG-2 alleles and a lambda1 light-chain transgene into the quasi-monoclonal (QM) mouse, which contains a "knocked-in" V(H)DJ(H) rearrangement. Thus, this mouse, which we call MonoB, is devoid of T cells and contains preformed heavy- and light-chain genes encoding immunoglobulin with an anti-NP specificity. The MonoB mouse allows...

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Source

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Identifiers

PMID: 10636478
DOI: 10.1155/1999/24514
PMCID: PMC2276038

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Source receipt: pubmed, retrieved 7 Sept 2026.

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