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Article

Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice.

Molecular immunology - 1 Apr 2006

Suárez Eduardo, Magadán Susana, Sanjuán Irene, Valladares Mónica, Molina Ana, Gambón Francisco, Díaz-Espada Fernando, González-Fernández Africa

Abstract excerpt

In recent years, mice carrying human IG transgenes are being generated for the production of human monoclonal antibodies as an alternative approach to the conventional use of mouse or chimeric-humanized antibodies. Theoretically, the size of the repertoire of human antibodies that these mice could produce would be critically dependent on the number of human V genes introduced in the transgene. This could be the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Rearrangement, B-Lymphocyte

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Source

Identifiers

PMID: 16343622
DOI: 10.1016/j.molimm.2005.10.015

Genes

IGK
IGL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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