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Article

High-resolution mapping of gene expression using association in an outbred mouse stock.

PLoS genetics - 8 Aug 2008

Ghazalpour Anatole, Doss Sudheer, Kang Hyun, Farber Charles, Wen Ping-Zi, Brozell Alec, Castellanos Ruth, Eskin Eleazar, Smith Desmond J, Drake Thomas A, Lusis Aldons J

Abstract excerpt

Quantitative trait locus (QTL) analysis is a powerful tool for mapping genes for complex traits in mice, but its utility is limited by poor resolution. A promising mapping approach is association analysis in outbred stocks or different inbred strains. As a proof of concept for the association approach, we applied whole-genome association analysis to hepatic gene expression traits in an outbred mouse population,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18688273
DOI: 10.1371/journal.pgen.1000149
PMCID: PMC2483929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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