Article
Commercially available outbred mice for genome-wide association studies.
PLoS genetics - 2 Sept 2010
Yalcin Binnaz, Nicod Jérôme, Bhomra Amarjit, Davidson Stuart, Cleak James, Farinelli Laurent, Østerås Magne, Whitley Adam, Yuan Wei, Gan Xiangchao, Goodson Martin, Klenerman Paul, Satpathy Ansu, Mathis Diane, Benoist Christophe, Adams David J, Mott Richard, Flint Jonathan
Abstract excerpt
Genome-wide association studies using commercially available outbred mice can detect genes involved in phenotypes of biomedical interest. Useful populations need high-frequency alleles to ensure high power to detect quantitative trait loci (QTLs), low linkage disequilibrium between markers to obtain accurate mapping resolution, and an absence of population structure to prevent false positive associations. We...
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