Article
Genetic analysis of complex traits in the emerging Collaborative Cross.
Genome research - 1 Aug 2011
Aylor David L, Valdar William, Foulds-Mathes Wendy, Buus Ryan J, Verdugo Ricardo A, Baric Ralph S, Ferris Martin T, Frelinger Jeff A, Heise Mark, Frieman Matt B, Gralinski Lisa E, Bell Timothy A, Didion John D, Hua Kunjie, Nehrenberg Derrick L, Powell Christine L, Steigerwalt Jill, Xie Yuying, Kelada Samir N P, Collins Francis S, Yang Ivana V, Schwartz David A, Branstetter Lisa A, Chesler Elissa J, Miller Darla R, Spence Jason, Liu Eric Yi, McMillan Leonard, Sarkar Abhishek, Wang Jeremy, Wang Wei, Zhang Qi, Broman Karl W, Korstanje Ron, Durrant Caroline, Mott Richard, Iraqi Fuad A, Pomp Daniel, Threadgill David, de Villena Fernando Pardo-Manuel, Churchill Gary A
Abstract excerpt
The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. Here we describe an experiment that uses partially inbred CC lines to evaluate the genetic properties and utility of this emerging resource. Genome-wide analysis of the incipient strains reveals high genetic diversity, balanced allele frequencies, and dense, evenly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.