Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus.

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Article

Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998

Gu L, Weinreb A, Wang X P, Zack D J, Qiao J H, Weisbart R, Lusis A J

Abstract excerpt

MRL-lpr/lpr (MRL/lpr) mice are a model of human autoimmune disease. They exhibit a number of characteristics of systemic lupus erythematosus, including anti-DNA Abs, anti-cardiolipin Abs, immune complex-mediated vasculitis, lymphadenopathy, and severe glomerulonephritis. Although the autoimmune d...

Topics

Animals
Autoantibodies
Autoimmune Diseases
Autoimmunity
Cholesterol, Dietary
Chromosome Mapping
Coronary Disease
Crosses, Genetic
Diet, Atherogenic
Dietary Fats
Disease Models, Animal
Female
Genetic Predisposition to Disease
Humans
Lipids
Lod Score
Lupus Erythematosus, Systemic
Male

Source

Open in PubMed

Identifiers

PMID: 9862736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9862736-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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