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Article

Circulating CSF-1 promotes monocyte and macrophage phenotypes that enhance lupus nephritis.

Journal of the American Society of Nephrology : JASN - 1 Dec 2009

Menke Julia, Rabacal Whitney A, Byrne Katelyn T, Iwata Yasunori, Schwartz Melvin M, Stanley E Richard, Schwarting Andreas, Kelley Vicki R

Abstract excerpt

Macrophages mediate kidney disease and are prominent in a mouse model (MRL-Fas(lpr)) of lupus nephritis. Colony stimulating factor-1 (CSF-1) is the primary growth factor for macrophages, and CSF-1 deficiency protects MRL-Fas(lpr) mice from kidney disease and systemic illness. Whether this renopro...

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Source

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Identifiers

PMID: 19926892
DOI: 10.1681/ASN.2009050499
PMCID: PMC2794229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19926892-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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