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Article

Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice.

PloS one - 1 Jan 2017

Nickerson Kevin M, Wang Yujuan, Bastacky Sheldon, Shlomchik Mark J

Abstract excerpt

Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on Fas-deficiency rather than lupus-promoting genes in the MRL genetic background. Here we report the effects of TLR9 deficiency on autoimmune disease independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

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Source

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Identifiers

PMID: 28278279
DOI: 10.1371/journal.pone.0173471
PMCID: PMC5344451

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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