Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci.

Reviews in immunogenetics - 1 Jan 2000

Nose M, Nishihara M, Kamogawa J, Terada M, Nakatsuru S

Abstract excerpt

MRL/MpJ-lpr/lpr (MRL/lpr) mice spontaneously develop various forms of autoimmune disease in the same individuals, including glomerulonephritis, polyarteritis, arthritis and sialoadenitis. An MRL recombinant congenic strain of mice bearing the gld gene, MRLiMpTn-gld/gld (MRL/gld), also develops lesions similar to those in MRL/lpr mice. The lpr and gld genes are a Fas deletion mutant and a Fas ligand mutant,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to fas Receptor

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Mice, Inbred MRL lpr

Share to Phenotype

Source

Identifiers

PMID: 11324688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci.PMID 11324688Read ↗

Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice.Semantic proximity Read ↗

Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis.Semantic proximity Read ↗

Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models.Semantic proximity Read ↗

Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains.Semantic proximity Read ↗

Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele.Semantic proximity Read ↗

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.Semantic proximity Read ↗

Genetic basis of tissue specificity of vasculitis in MRL/lpr mice.Semantic proximity Read ↗

Host modifier genes affect mouse autoimmunity induced by the lpr gene.Semantic proximity Read ↗

Distinctive expression of lprcg in the heterozygous state on different genetic backgrounds.Semantic proximity Read ↗

Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

High expression of interleukin-1beta in the corneal epithelium of MRL/lpr mice is under the control of their genetic background.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.