Article
Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds.
Cancer research - 15 Aug 1991
Peltomäki P, Sistonen P, Mecklin J P, Pylkkänen L, Järvinen H, Simons J W, Cho K R, Vogelstein B, de la Chapelle A
Abstract excerpt
Hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome is characterized by early onset and multiple cancers of predominantly the proximal colon and occasionally other organs. The mode of transmission is compatible with autosomal dominant inheritance but the location and characteristics of the putative susceptibility gene are unknown. We performed linkage analyses with the aim of proving or excluding the...
Topics
- Adult
- Alleles
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 18
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Probes
- Female
- Genetic Linkage