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Article

Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer.

Gastroenterology - 1 Jun 1998

Carethers J M, Hawn M T, Greenson J K, Hitchcock C L, Boland C R

Abstract excerpt

BACKGROUND & AIMS: Allelic loss of a portion of chromosome 18q and lack of expression of deleted in colorectal cancer (DCC) protein has been reported as an adverse prognostic indicator for stage II (i.e., Dukes' B2) colorectal cancer. Our aim was to assess whether the DCC gene locus was responsible. METHODS: We amplified five DNA microsatellite markers located on chromosome 18q21 surrounding or within the DCC...

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Identifiers

PMID: 9609755
DOI: 10.1016/s0016-5085(98)70424-x

Genes

DCC

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