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Article

Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.

Oncogene - 20 Nov 2008

Mao J H, Wu D, DelRosario R, Castellanos A, Balmain A, Perez-Losada J

Abstract excerpt

Ataxia-Telangiectasia (A-T) is an autosomal recessive human disease characterized by genetic instability, radiosensitivity, immunodeficiency and cancer predisposition, because of mutation in both alleles of the ATM (ataxia-telangiectasia mutated) gene. The role of Atm heterozygosity in cancer susceptibility is controversial, in both human and mouse. Earlier studies identified deletions near the Atm gene on mouse...

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Source

Identifiers

PMID: 18679420
DOI: 10.1038/onc.2008.280

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.PMID 18679420Read ↗

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.Semantic proximity Read ↗

Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.Semantic proximity Read ↗

Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues.Semantic proximity Read ↗

Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.Semantic proximity Read ↗

Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.Semantic proximity Read ↗

Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice.Semantic proximity Read ↗

Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.Semantic proximity Read ↗

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors.Semantic proximity Read ↗

Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.Semantic proximity Read ↗

High incidence of cancer in a family segregating a mutation of the ATM gene: possible role of ATM heterozygosity in cancer.Semantic proximity Read ↗

Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.Semantic proximity Read ↗

Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation.Semantic proximity Read ↗

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