Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.

Molecular cancer research : MCR - 1 Dec 2007

Gurley Kay E, Kemp Christopher J

Abstract excerpt

The ataxia-telangiectasia mutated (Atm) protein kinase is a central regulator of the cellular response to DNA damage. Although Atm can regulate p53, it is not known if this Atm function varies between tissues. Previous studies showed that the induction of p53 and apoptosis by whole-body ionizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Epidermis
Share to Epithelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Follicle

Share to Intestine, Small

Share to Lymphoid Tissue

Share to Organ Specificity

Share to Whole-Body Irradiation

Source

Identifiers

PMID: 18171989
DOI: 10.1158/1541-7786.MCR-07-0223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18171989-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.PMID 18171989Read ↗

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system.Semantic proximity Read ↗

Atm-deficient mice: a paradigm of ataxia telangiectasia.Semantic proximity Read ↗

ATM&A Key Determinant of Multiple Cellular Responses to IrradiationSemantic proximity Read ↗

ATM-Dependent and -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, and UV IrradiationSemantic proximity Read ↗

Ataxia-telangiectasia and cellular responses to DNA damage.Semantic proximity Read ↗

Contribution of the Atm Protein to Maintaining Cellular Homeostasis Evidenced by Continuous Activation of the AP-1 Pathway in Atm-deficient BrainsSemantic proximity Read ↗

Atm-null mice exhibit enhanced radiation-induced birth defects and a hybrid form of embryonic programmed cell death indicating a teratological suppressor function for ATM.Semantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues.Semantic proximity Read ↗

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.Semantic proximity Read ↗

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.Semantic proximity Read ↗

Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.