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Article

Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues.

Radiation research - 1 Jul 2006

Connolly Lanelle, Lasarev Michael, Jordan Robert, Schwartz Jeffrey L, Turker Mitchell S

Abstract excerpt

Ataxia telangiectasia (AT) is a hereditary disease with autosomal recessive inheritance of ATM (ataxia telangiectasia mutation) alleles. AT is associated with severe sensitivity to ionizing radiation and a strong predisposition to develop cancer. A modest increase in cancer, particularly for the breast, has been shown for ATM carriers (i.e. heterozygotes), and a modest increase in radiation sensitivity has also...

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Source

Identifiers

PMID: 16808618
DOI: 10.1667/RR3578.1

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues.PMID 16808618Read ↗

Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations.Semantic proximity Read ↗

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors.Semantic proximity Read ↗

Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.Semantic proximity Read ↗

Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.Semantic proximity Read ↗

Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.Semantic proximity Read ↗

A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events.Semantic proximity Read ↗

Effect of Atm disruption on spontaneously arising and radiation-induced deletion mutations in mouse liver.Semantic proximity Read ↗

Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress.Semantic proximity Read ↗

Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.Semantic proximity Read ↗

Tissue-specific deletion and discontinuous loss of heterozygosity are signatures for the mutagenic effects of ionizing radiation in solid tissues.Semantic proximity Read ↗

Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.Semantic proximity Read ↗

Age-related accumulation of autosomal mutations in solid tissues of the mouse is gender and cell type specific.Semantic proximity Read ↗

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