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Article

Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.

Cancer research - 15 Jan 2000

Bishop A J, Barlow C, Wynshaw-Boris A J, Schiestl R H

Abstract excerpt

Ataxia telangiectasia (AT) patients have inactivating mutations in both copies of the ATM gene. The ATM protein that the gene encodes is involved in DNA double-strand break (DSB) recognition; in its absence, p53 response to DSBs is delayed and reduced. In addition, AT patients have a high propensity for cancer, and cells from these patients show chromosomal instability. Here, using an in vivo mouse model system...

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Source

Identifiers

PMID: 10667593

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.PMID 10667593Read ↗

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