Article
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.
Nature genetics - 1 Sept 2002
Spring Kevin, Ahangari Farida, Scott Shaun P, Waring Paul, Purdie David M, Chen Philip C, Hourigan Kevin, Ramsay Jonathan, McKinnon Peter J, Swift Michael, Lavin Martin F
Abstract excerpt
Ataxia-telangiectasia is characterized by radiosensitivity, genome instability and predisposition to cancer. Heterozygous carriers of ATM, the gene defective in ataxia-telangiectasia, have a higher than normal risk of developing breast and other cancers. We demonstrate here that Atm 'knock-in' (Atm-Delta SRI) heterozygous mice harboring an in-frame deletion corresponding to the human 7636del9 mutation show an...
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