Article
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Cancer research - 1 Aug 2001
Smilenov L B, Brenner D J, Hall E J
Abstract excerpt
Subpopulations that are genetically predisposed to radiation-induced cancer could have significant public health consequences. Individuals homozygous for null mutations at the ataxia telangiectasia gene are indeed highly radiosensitive, but their numbers are very small. Ataxia Telangiectasia heterozygotes (1-2% of the population) have been associated with somewhat increased radiosensitivity for some end points,...
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