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Article

Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice.

Radiation research - 1 Nov 2007

Kleiman Norman J, David Janice, Elliston Carl D, Hopkins Kevin M, Smilenov Lubomir B, Brenner David J, Worgul Basil V, Hall Eric J, Lieberman Howard B

Abstract excerpt

Rad9 and Atm regulate multiple cellular responses to DNA damage, including cell cycle checkpoints, DNA repair and apoptosis. However, the impact of dual heterozygosity for Atm and Rad9 is unknown. Using 50 cGy of X rays as an environmental insult and cataractogenesis as an end point, this study examined the effect of heterozygosity for one or both genes in mice. Posterior subcapsular cataracts, characteristic of...

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Identifiers

PMID: 17973559
DOI: 10.1667/rr1122.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice.PMID 17973559Read ↗

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