Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.

Breast cancer research : BCR - 1 Jan 2005

Umesako Seiichi, Fujisawa Kae, Iiga Sayoko, Mori Nobuko, Takahashi Masahiro, Hong Doo-Pyo, Song Chang-Woo, Haga Satomi, Imai Syunsuke, Niwa Otsura, Okumoto Masaaki

Abstract excerpt

INTRODUCTION: Ataxia-telangiectasia is an autosomal-recessive disease that affects neuro-immunological functions, associated with increased susceptibility to malignancy, chromosomal instability and hypersensitivity to ionizing radiation. Although ataxia-telangiectasia mutated (ATM) heterozygous deficiency has been proposed to increase susceptibility to breast cancer, some studies have not found excess risk. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Loss of Heterozygosity

Share to Mammary Neoplasms, Animal

Share to Mice, Inbred BALB C

Share to Neoplasms, Radiation-Induced

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15642165
DOI: 10.1186/bcr968
PMCID: PMC1064114

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice.PMID 15642165Read ↗

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors.Semantic proximity Read ↗

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.Semantic proximity Read ↗

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.Semantic proximity Read ↗

ATM, radiation, and the risk of second primary breast cancer.Semantic proximity Read ↗

Cancer risk and the ATM gene: a continuing debate.Semantic proximity Read ↗

Allelic losses in mouse skin tumors induced by gamma-irradiation of p53 heterozygotes.Semantic proximity Read ↗

Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.Semantic proximity Read ↗

ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancerSemantic proximity Read ↗

Dominant negative ATM mutations in breast cancer families.Semantic proximity Read ↗

Upregulation of FasL and apoptosis in thymic lymphomas in Atm knock-in mice.Semantic proximity Read ↗

Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.Semantic proximity Read ↗

The role of ATM in breast cancer development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.