Article
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.
Cancer research - 1 Jun 2001
Spring K, Cross S, Li C, Watters D, Ben-Senior L, Waring P, Ahangari F, Lu S L, Chen P, Misko I, Paterson C, Kay G, Smorodinsky N I, Shiloh Y, Lavin M F
Abstract excerpt
ATM, the gene mutated in the human immunodeficiency disorder ataxia-telangiectasia (A-T), plays a central role in recognizing ionizing radiation damage in DNA and in controlling several cell cycle checkpoints. We describe here a murine model in which a nine-nucleotide in-frame deletion has been introduced into the Atm gene by homologous recombination followed by removal of the selectable marker cassette by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.