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Article

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.

PLoS genetics - 1 Aug 2008

Lindroth Anders M, Park Yoon Jung, McLean Chelsea M, Dokshin Gregoriy A, Persson Jenna M, Herman Herry, Pasini Diego, Miró Xavier, Donohoe Mary E, Lee Jeannie T, Helin Kristian, Soloway Paul D

Abstract excerpt

At the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27 trimethylation are mutually exclusive, with DNA and H3K27 methylation limited to the paternal and maternal sequences, respectively. The mutual exclusion arises because one mark prevents placement of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18670629
DOI: 10.1371/journal.pgen.1000145
PMCID: PMC2475503

Genes

DMD
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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