Article
Regulation of DNA methylation of Rasgrf1.
Nature genetics - 1 Jan 2002
Yoon Bong June, Herman Herry, Sikora Aimee, Smith Laura T, Plass Christoph, Soloway Paul D
Abstract excerpt
In mammals, DNA is methylated at cytosines within CpG dinucleotides. Properly regulated methylation is crucial for normal development. Inappropriate methylation may contribute to tumorigenesis by silencing tumor-suppressor genes or by activating growth-stimulating genes. Although many genes have been identified that acquire methylation and whose expression is methylation-sensitive, little is known about how DNA...
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