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Identification of genetic elements that autonomously determine DNA methylation states.

Nature genetics - 2 Oct 2011

Lienert Florian, Wirbelauer Christiane, Som Indrani, Dean Ann, Mohn Fabio, Schübeler Dirk

Abstract excerpt

Cytosine methylation is a repressive, epigenetically propagated DNA modification. Although patterns of DNA methylation seem tightly regulated in mammals, it is unclear how these are specified and to what extent this process entails genetic or epigenetic regulation. To dissect the role of the underlying DNA sequence, we sequentially inserted over 50 different DNA elements into the same genomic locus in mouse stem...

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PMID: 21964573
DOI: 10.1038/ng.946

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