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Article

A non-coding RNA within the Rasgrf1 locus in mouse is imprinted and regulated by its homologous chromosome in trans.

PloS one - 2 Nov 2010

Brideau Chelsea M, Kauppinen Krista P, Holmes Rebecca, Soloway Paul D

Abstract excerpt

BACKGROUND: Rasgrf1 is imprinted in mouse, displaying paternal allele specific expression in neonatal brain. Paternal expression is accompanied by paternal-specific DNA methylation at a differentially methylated domain (DMD) within the locus. The cis-acting elements necessary for Rasgrf1 imprinting are known. A series of tandem DNA repeats control methylation of the adjacent DMD, which is a methylation sensitive...

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Source

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Identifiers

PMID: 21072176
DOI: 10.1371/journal.pone.0013784
PMCID: PMC2970558

Genes

DMD

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Source receipt: pubmed, retrieved 7 Sept 2026.

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