Article
Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals.
Human molecular genetics - 15 Sept 2009
Henckel Amandine, Nakabayashi Kazuhiko, Sanz Lionel A, Feil Robert, Hata Kenichiro, Arnaud Philippe
Abstract excerpt
Mono-allelic expression of imprinted genes from either the paternal or the maternal allele is mediated by imprinting control regions (ICRs), which are epigenetically marked in an allele-specific fashion. Although, in somatic cells, these epigenetic marks comprise both DNA methylation and histone methylation, the relationship between these two modifications in imprint acquisition and maintenance remains unclear....
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