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Article

Differential methylation persists at the mouse Rasgrf1 DMR in tissues displaying monoallelic and biallelic expression.

Epigenetics - 16 May 2009

Dockery Lauren, Gerfen Jennifer, Harview Christina, Rahn-Lee Charlotte, Horton Rachel, Park Yaena, Davis Tamara L

Abstract excerpt

A subset of mammalian genes exhibits genomic imprinting, whereby one parental allele is preferentially expressed. Differential DNA methylation at imprinted loci serves both to mark the parental origin of the alleles and to regulate their expression. In mouse, the imprinted gene Rasgrf1 is associated with a paternally methylated imprinting control region which functions as an enhancer blocker in its unmethylated...

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Identifiers

PMID: 19502804
DOI: 10.4161/epi.9021
PMCID: PMC2872782

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