NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populations.

doi:10.1111/j.1440-1711.2005.01311.x

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Article

NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populations.

Immunology and cell biology - 1 Apr 2005

Scalzo Anthony A, Manzur Mitali, Forbes Catherine A, Brown Michael G, Shellam Geoffrey R

Abstract excerpt

The NK gene complex (NKC) on mouse chromosome 6 encodes receptors that are expressed on NK cells, such as Ly49H, and is involved in regulating NK cell control of virus infections, such as murine cytomegalovirus (MCMV). In the present study, we investigated the level of allelic heterogeneity in NKC loci in populations of outbred wild mice. This work revealed extensive levels of heterogeneity within two wild mouse...

Topics

Animals
Genetic Variation
Haplotypes
Herpesviridae Infections
Immunity
Killer Cells, Natural
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Muromegalovirus
Receptors, Cell Surface
Specific Pathogen-Free Organisms

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Open in PubMed

Identifiers

PMID: 15748210
DOI: 10.1111/j.1440-1711.2005.01311.x

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