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Article

Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer.

Genes, chromosomes & cancer - 1 Nov 2008

Pappas Jane J, Toulouse André, Hébert Josée, Fetni Raouf, Bradley W E C

Abstract excerpt

Retinoic acid receptor B2 (RARB2) is frequently inactivated in cancer. Methylation in the 5'-untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that hypo- and hypermethylated alleles coexist in 5/11 cell lines in which RARB2 is inactivated. We present evidence supporting the mitotic transmission of these...

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Share to CpG Islands
Share to Cell Line, Tumor
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to In Situ Hybridization, Fluorescence

Share to Neoplasms

Share to Promoter Regions, Genetic

Share to Receptors, Retinoic Acid

Source

Identifiers

PMID: 18663751
DOI: 10.1002/gcc.20603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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