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Article

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing

8 Jan 2013

Abstract excerpt

Retinoic acid receptor β 2 ( RAR β 2 ) is a tumor suppressor gene whose loss of expression is recurrent in prostate cancers. Here we studied the epigenetic mechanisms leading to its stable silencing. First, we characterized all RAR β isoforms in 6 human tumor cell lines (prostate DU145, LNCaP, PC3, lung A549, breast Hs578T, and colon HCT116) by RT‐PCR and Western blot. We excluded loss of heterozygosity (2D‐FISH)...

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PMID: 23299856
DOI: 10.1096/fj.12-210971

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