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Article

Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

Cancer research - 15 Jul 2003

Yuan Jiuhong, Luo Robert Z, Fujii Satoshi, Wang Lin, Hu Wei, Andreeff Michael, Pan Yong, Kadota Mitsutaka, Oshimura Mitsuo, Sahin Aysegul A, Issa Jean-Pierre, Bast Robert C, Yu Yinhua

Abstract excerpt

ARHI is a maternally imprinted tumor suppressor gene that maps to a site on chromosome 1p31 where loss of heterozygosity has been observed in 40% of human breast and ovarian cancers. ARHI is expressed in normal ovarian and breast epithelial cells, but ARHI expression is lost in a majority of ovarian and breast cancers. Expression of ARHI from the paternal allele can be down-regulated by multiple mechanisms in...

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PMID: 12874023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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