Article
Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.
Molecular and cellular biology - 1 Dec 2005
Ren Mingqiang, Pozzi Silvia, Bistulfi Gaia, Somenzi Giulia, Rossetti Stefano, Sacchi Nicoletta
Abstract excerpt
Resistance to the growth-inhibitory action of retinoic acid (RA), the bioactive derivative of vitamin A, is common in human tumors. One form of RA resistance has been associated with silencing and hypermethylation of the retinoic acid receptor beta2 gene (RARbeta2), an RA-regulated tumor suppressor gene. The presence of an epigenetically silent RARbeta2 correlates with lack of the RA receptor alpha (RARalpha)....
Topics
- Cell Line, Tumor
- DNA
- DNA Methylation
- Drug Resistance
- Epigenesis, Genetic
- Gene Silencing
- Humans
- Phenotype
- RNA Interference
- Receptors, Retinoic Acid
- Retinoic Acid Receptor alpha
- Signal Transduction
- Transcription, Genetic
- Tretinoin