Article
Aberrant allele-specific replication, independent of parental origin, in blood cells of cancer patients.
BMC cancer - 25 Dec 2008
Dotan Zohar A, Dotan Aviva, Ramon Jacob, Avivi Lydia
Abstract excerpt
BACKGROUND: Allelic counterparts of biallelically expressed genes display an epigenetic symmetry normally manifested by synchronous replication, different from genes subjected to monoallelic expression, which normally are characterized by an asynchronous mode of replication (well exemplified by the SNRPN imprinted locus). Malignancy was documented to be associated with gross modifications in the inherent...
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