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Article

Methylation and Silencing of the Retinoic Acid Receptor- 2 Gene in Breast Cancer

17 May 2000

Abstract excerpt

BACKGROUND: A growing body of evidence supports the hypotheses that the retinoic acid receptor beta2 (RAR-beta2) gene is a tumor suppressor gene and that the chemopreventive effects of retinoids are due to induction of RAR-beta2. RAR-beta2 expression is reduced in many malignant tumors, and we examined whether methylation of RAR-beta2 could be responsible for this silencing. METHODS: RAR-beta2 expression was...

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PMID: 10814678
DOI: 10.1093/jnci/92.10.826

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