Article
Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer.
The American journal of pathology - 1 Jan 2001
Yang Q, Mori I, Shan L, Nakamura M, Nakamura Y, Utsunomiya H, Yoshimura G, Suzuma T, Tamaki T, Umemura T, Sakurai T, Kakudo K
Abstract excerpt
A growing body of evidence supports the hypotheses that retinoic acid receptor beta2 (RAR beta2) is a tumor suppressor gene. Although the loss of RAR beta2 expression has been reported in many malignant tumors, including breast cancer, the molecular mechanism is still poorly understood. We hypothesized that loss of RAR beta2 activity could result from multiple factors, including epigenetic modification and loss...
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