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Article

PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.

Oncogene - 23 Oct 2008

Kotadia S, Kao L R, Comerford S A, Jones R T, Hammer R E, Megraw T L

Abstract excerpt

Viruses of the DNA tumor virus family share the ability to transform vertebrate cells through the action of virus-encoded tumor antigens that interfere with normal cell physiology. They accomplish this very efficiently by inhibiting endogenous tumor suppressor proteins that control cell proliferation and apoptosis. Simian virus 40 (SV40) encodes two oncoproteins, large tumor antigen, which directly inhibits the...

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Share to Antigens, Polyomavirus Transforming
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Embryo, Nonmammalian

Share to Fluorescent Antibody Technique, Indirect

Share to Glutathione Transferase

Share to Protein Phosphatase 2

Share to Simian virus 40

Source

Open in PubMed Open full text

Identifiers

PMID: 18663356
DOI: 10.1038/onc.2008.254
PMCID: PMC2575340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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