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Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

28 Aug 2017

Abstract excerpt

The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication,...

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PMID: 28846109
DOI: 10.1038/onc.2017.277

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