Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation.

Journal of cell science - 1 Jun 2003

Murphy Terence D

Abstract excerpt

Centrosome duplication must be coupled to the main cell cycle to ensure that each cell has precisely two centrosomes at the onset of mitosis. Supernumerary centrosomes are commonly observed in cancer cells, and may contribute to tumorigenesis. Drosophila skpA, a component of SCF ubiquitin ligases, regulates the link between the cell and centrosome cycles. Lethal skpA null mutants exhibit dramatic centrosome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Nucleus
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin E

Share to Cytoplasm

Share to Drosophila

Share to Genes, Lethal

Share to SKP Cullin F-Box Protein Ligases

Source

Identifiers

PMID: 12730292
DOI: 10.1242/jcs.00463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation.PMID 12730292Read ↗

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.Semantic proximity Read ↗

The centrosome cycleSemantic proximity Read ↗

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin ASemantic proximity Read ↗

An updated view on the centrosome as a cell cycle regulatorSemantic proximity Read ↗

The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila.Semantic proximity Read ↗

Drosophila Cks30A interacts with Cdk1 to target Cyclin A for destruction in the female germline.Semantic proximity Read ↗

Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome StabilitySemantic proximity Read ↗

Sufu negatively regulates both initiations of centrosome duplication and DNA replication.Semantic proximity Read ↗

Centrosome amplification, chromosome instability and cancer development.Semantic proximity Read ↗

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.Semantic proximity Read ↗

<i>Spd-2</i> Gene Duplication Suggests Cell-Type Specific Assembly Mechanisms of Pericentriolar MaterialSemantic proximity Read ↗

Regulation of the cell cycle and centrosome biology by deubiquitylasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.