Article
Activation domain-dependent degradation of somatic Wee1 kinase.
The Journal of biological chemistry - 26 Feb 2010
Owens Laura, Simanski Scott, Squire Christopher, Smith Anthony, Cartzendafner Jeff, Cavett Valerie, Caldwell Busby Jennifer, Sato Trey, Ayad Nagi G
Abstract excerpt
Cell cycle progression is dependent upon coordinate regulation of kinase and proteolytic pathways. Inhibitors of cell cycle transitions are degraded to allow progression into the subsequent cell cycle phase. For example, the tyrosine kinase and Cdk1 inhibitor Wee1 is degraded during G(2) and mitosis to allow mitotic progression. Previous studies suggested that the N terminus of Wee1 directs Wee1 destruction....
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