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Article

USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

26 Nov 2012

Abstract excerpt

Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). The deubiquitinase USP44 was identified as a key regulator of APC activation; however, the physiological importance of USP44 and its impact on cancer biology are unknown. To clarify...

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PMID: 23187126
DOI: 10.1172/jci63084

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