Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen

doi:10.1128/jvi.00157-15

Article

Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen

29 Jan 2015

Abstract excerpt

UNLABELLED: Merkel cell polyomavirus (MCV) is a newly discovered human cancer virus encoding a small T (sT) oncoprotein. We performed MCV sT FLAG-affinity purification followed by mass spectroscopy (MS) analysis, which identified several protein phosphatases (PP), including PP2A A and C subunits and PP4C, as potential cellular interacting proteins. PP2A targeting is critical for the transforming properties of...

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