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Article

Formation of noncanonical DNA structures mediated by human ORC4, a protein component of the origin recognition complex.

Biochemistry - 19 Aug 2008

Stefanovic Dragana, Kusic Jelena, Divac Aleksandra, Tomic Branko

Abstract excerpt

Many genomic sequences, DNA replication origins included, contain specific structural motifs prone to alternative base pairing. Structural rearrangements of DNA require specific environmental conditions and could be favored by chemical agents or proteins. To improve our understanding of alternative conformations of origins and the manner in which they form, we have investigated the effect of DNA-binding, AAA+...

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Source

Identifiers

PMID: 18652488
DOI: 10.1021/bi800684f

Genes

ORC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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