Article
MAST3: a novel IBD risk factor that modulates TLR4 signaling.
Genes and immunity - 1 Oct 2008
Labbé C, Goyette P, Lefebvre C, Stevens C, Green T, Tello-Ruiz M K, Cao Z, Landry A L, Stempak J, Annese V, Latiano A, Brant S R, Duerr R H, Taylor K D, Cho J H, Steinhart A H, Daly M J, Silverberg M S, Xavier R J, Rioux J D
Abstract excerpt
Inflammatory bowel disease (IBD) is a chronic disorder caused by multiple factors in a genetically susceptible host. Significant advances in the study of genetic susceptibility have highlighted the importance of the innate immune system in this disease. We previously completed a genome-wide linkage study and found a significant locus (IBD6) on chromosome 19p. We were interested in identifying the causal variant...
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