Article
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.
Genes and immunity - 1 Jul 2007
De Jager P L, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield G P, Dubois B, Cho J H, Brant S R, Duerr R H, Yang H, Rotter J I, Silverberg M S, Steinhart A H, Daly M J, Podolsky D K, Louis E, Hafler D A, Rioux J D
Abstract excerpt
The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a...
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