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Article

A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.

Journal of cellular and molecular medicine - 1 Apr 2018

Wu William K K, Sun Rui, Zuo Tao, Tian Yuanyuan, Zeng Zhirong, Ho Jeffery, Wu Justin C Y, Chan Francis K L, Chan Matthew T V, Yu Jun, Sung Joseph J Y, Wong Sunny H, Wang Maggie H, Ng Siew C

Abstract excerpt

The incidence of Crohn's disease is increasing in many Asian countries, but considerable differences in genetic susceptibility have been reported between Western and Asian populations. This study aimed to fine-map 23 previously reported Crohn's disease genes and identify their interactions in the Chinese population by Illumina-based targeted capture sequencing. Our results showed that the genetic polymorphism A>G...

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Identifiers

PMID: 29441677
DOI: 10.1111/jcmm.13530
PMCID: PMC5867068

Genes

MST1
JAK2
NOD2

Provenance

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