Article
Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.
Mucosal immunology - 1 Mar 2008
Goyette P, Lefebvre C, Ng A, Brant S R, Cho J H, Duerr R H, Silverberg M S, Taylor K D, Latiano A, Aumais G, Deslandres C, Jobin G, Annese V, Daly M J, Xavier R J, Rioux J D
Abstract excerpt
Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus been pursuing a region on chromosome 3p21-22 showing linkage to CD and ulcerative colitis (UC) using...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Colitis, Ulcerative
- Crohn Disease
- Female
- Genetic Predisposition to Disease
- Genome, Human
- Hepatocyte Growth Factor
- Humans
- Linkage Disequilibrium