Article
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Gut - 1 Aug 2009
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt K A, Turner G, Bruinenberg M, Heap G A, Platteel M, Ryan A W, de Kovel C, Holmes G K T, Howdle P D, Walters J R F, Sanders D S, Mulder C J J, Mearin M L, Verbeek W H M, Trimble V, Stevens F M, Kelleher D, Barisani D, Bardella M T, McManus R, van Heel D A, Wijmenga C
Abstract excerpt
OBJECTIVE: Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more modest association in the GWAS for genotyping and analysis in four independent cohorts. DESIGN: 458 SNPs were assayed in 1682...
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