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Article

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

5 Jun 2007

Abstract excerpt

CpG-DNA or its synthetic analog CpG-ODN activates innate immunity through Toll-like receptor 9 (TLR9). However, the mechanism of TLR9 activation by CpG-DNA remains elusive. Here we have identified HMGB1 as a CpG-ODN-binding protein. HMGB1 interacts and preassociates with TLR9 in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC), and hastens TLR9's redistribution to early endosomes in response to...

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PMID: 17548579
DOI: 10.1182/blood-2006-09-044776

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