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Article

Role of TLR9 in Oncogenic Virus-Produced Cancer

2 Feb 2017

Abstract excerpt

Nucleic acid recognition by toll-like receptor 9 (TLR9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type I interferons, as well as many other molecules required to initialize the immune response. The use of synthetic oligodeoxynucleotides (ODNs) has been crucial to emulate the recognition of DNA sequences by TLR9. Furthermore, ODN administration to mice has shown to...

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PMID: 28151089
DOI: 10.1089/vim.2016.0103

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